Clotrimazole
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Clotrimazole
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| Systematic (IUPAC) name | |
| 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole | |
| Identifiers | |
| CAS number | |
| ATC code | A01 D01AC01, G01AF02 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C22H17ClN2 |
| Mol. mass | 344.837 g/mol |
| Pharmacokinetic data | |
| Bioavailability | Poorly and erratically absorbed orally |
| Protein binding | 90% |
| Metabolism | hepatic |
| Half life | 2 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status |
P(UK) |
| Routes | topical |
Clotrimazole is an antifungal medication commonly used in the treatment of fungal infections of both humans and animals such as vaginal yeast infections and ringworm. It also used to treat athlete's foot and jock itch.
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[edit] Indications and formulations
It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, and also (especially in the case of ear infection) as a combination medicine. In the latter case, it typically includes an antibiotic such as Marbofloxacin, and is applied in liquid form, as ear drops.
Fungal infections can be slow to clear up, so the usual course for an anti-fungal agent is generally longer than the typical 3-7 days of an antibiotic.
Women who suffer from vaginal yeast infections, such as candidiasis, can buy clotrimazole at a pharmacy. However, women should contact their doctor on the first occurrence of a vaginal yeast infection instead of self-diagnosing.
In the UK, Australia, Canada, Germany, and parts of Latin America and the Caribbean the drug is marketed under the name Canesten.
[edit] Drug interactions
There is the potential for drug interactions with Clotrimazole if taken orally, as it is a potent, specific inhibitor of cytochrome P450 oxidase enzymes and so may alter the metabolism of other drugs.
[edit] Side effects
Occasionally may cause localised irritation of the skin with a mild burning sensation, redness and itching.
[edit] External links
- MedlinePlus - Clotrimazole (Topical)
- MedlinePlus - Clotrimazole
- Links to external chemical sources
| Antifungals (D01 and J02) | |
|---|---|
| Antibiotics | Griseofulvin, Hitachimycin, Natamycin, Nystatin |
| Topical Azoles | Clotrimazole, Econazole, Fluconazole, Ketoconazole, Miconazole, Oxiconazole, Sertaconazole, Sulconazole, Tioconazole |
| Other topicals | Ciclopirox, Ethylparaben, Flucytosine, Salicylic acid, Selenium sulfide, Terbinafine, Tolnaftate |
| For systemic use | Amphotericin B, Anidulafungin, Caspofungin, Griseofulvin, Itraconazole, Terbinafine, Voriconazole |
| Other | Posaconazole, Thiabendazole, Tea tree oil |
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