Class II PI 3-kinases

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Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.

Class II PI 3-kinases were the most recently identified class of PI 3-kinases and little is currently known about these enzymes.

There are three class II PI 3-kinase isoforms expressed in mammalian cells;

  • PI3K-C2α
  • PI3K-C2β
  • PI3K-C2γ

[edit] See also

phosphoinositide 3-kinase

[edit] References

  • Stein RC( 2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment Endocr Relat Cancer 8:237-248 [1]
  • Foster FM, Traer CJ, Abraham SM, and Fry MJ (2003) The phosphoinositide (PI) 3-kinase family J Cell Sci 116:3037-3040.[2]
  • Vanhaesebroeck B, Waterfield MD.(1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 253(1):239-54.[3]


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v • d • e
Transferase: kinases (EC 2.7)

Adenylate - Creatine - Gluco- - Hexo- - Nucleoside-diphosphate - Phosphoinositide 3 (Class I PI 3, Class II PI 3) - Phosphofructo- - Pyruvate - Thymidine

Protein kinases: Serine/threonine-specific - Tyrosine

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