Chordin
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| Chordin | |
|---|---|
| Genetic data | |
| Gene code: | HUGO code:CHRD |
| Protein Structure/Function | |
| Protein type: | chordin family member |
| Functions: | dorsalizing factor |
| Domains: | 4 CHRD domains, 4 VWFC domains |
| Other | |
| Taxa expressing: | many metazoan phyla |
| Cell types: | many |
| Subcellular localization: | extracellular |
Chordin is a polypeptide that dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as Bone morphogenetic proteins. It may also play a role in organogenesis. There are five named isoforms of this protein that are produced by alternative splicing.
| Identifiers | |
| Symbol | CHRD |
| HUGO | 1949 |
| Entrez | 8646 |
| OMIM | 603475 |
| RefSeq | NM_003741 |
| UniProt | Q9H2X0 |
| Other data | |
| Locus | Chr. 3 q27 |
TGF beta superfamily of ligands:
Activin A and B - Anti-müllerian hormone - Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) - Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF9, GDF10, GDF11, GDF15) - Inhibin A and B - Myostatin - Nodal - TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Type II receptors:ACVR2A - ACVR2B - AMHR2 - BMPR2 - TGFBR2 - TGFBR3
Type I receptors: ACVR1A - ACVR1B - ACVR1C - ACVRL1 - BMPR1A - BMPR1B - TGFBR1
Signal transducers/SMAD: R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors: Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
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