Cholesterol 7 alpha-hydroxylase
From Wikipedia, the free encyclopedia
|
cytochrome P450, family 7, subfamily A, polypeptide 1
|
|
| Identifiers | |
| Symbol | CYP7A1 CYP7 |
| HUGO | 2651 |
| Entrez | 1581 |
| OMIM | 118455 |
| RefSeq | NM_000780 |
| UniProt | P22680 |
| Other data | |
| EC number | 1.14.13.17 |
| Locus | Chr. 8 q11-q12 |
Cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the synthesis of bile acid from cholesterol.
It is downregulated by Sterol regulatory element binding proteins (SREBP) when plasma cholesterol levels are low.
