Talk:Chlorhexidine gluconate
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[edit] Query
Is there any evidence that chlorhexidine is also efficent against viral infection?
[edit] Error of fact
A study Efficacy of chlorhexidine mouthrinses with and without alcohol: a clinical study. used mouthwashes with chlorhexidine and fluoride and finds them to be effective. In fact that was just assumed, the issue was trying to decide if that formula with and without alcohol was just as effective and they found it was. Maybe it has to be specially formulated, I don't know, but clearly they are not entirely incompatible. - Taxman 23:16, May 4, 2005 (UTC)
I have this chemical in my hands right at this moment, and it says right on the label that getting it requires a prescription in the United States. Fact has been updated.
I have used this and the product is often packaged as a Colgate product. It does require a prescription to obtain.
[edit] Incorrect title for chemical structue
The structure shown is of course not of the gluconate salt of the substance, but of neutral chlorhexidine. I tried to correct the title of the picture, but it seems to be auto-generated from the title of the article (?) by the "drugbox" template. Perhaps someone with more knowledge about the internals of wikipedia could correct this? Alternatively, I would suggest moving the article to "chlorhexidine", as this is the general substance - of course the article can then mention, that it's most of the time administered as the gluconate. Iridos 11:40, 4 July 2006 (UTC)
[edit] More questions for an expert
Is chlorhexidine gluconate the same as chlorhexidine digluconate? I've seen the 'digluconate' from mentioned on some mouthwashes. It could be mentioned that in the U.K. there is no need for a prescription - it is above every sink in hospitals. And you can buy the mouthwash in a chemist's. - jehh87 17:18 Aug 5, 2006 (UTC)
[edit] Brown Tooth Enamel Staining
My dental hygienist who mentioned chlorahexidine as a treatment for eradicating periodontal bacteria said that it was a drastic treatment meant for very few dental cases since it had a side effect of causing some degree of brown staining of the tooth enamel, and the treatments involved a strict regiment of at least a week of repeat in home rinse applications after each meal or snack.Oldspammer 08:50, 13 August 2006 (UTC)
[edit] Acute Gingavitis Alternate Treatment
Gingivitis paragraph 2 under "Causes" (2006-August) mentions "Fortunately, this (trenchmouth a.k.a. Acute Necrotizing Ulcerative Gingitivitis) can be cured with a 1-week dose of Metronidazole antibiotic, followed by a deep cleaning of the gums by a dentist." The Metronidazole article mentions that it is a treatment for "Acute gingivitis and other dental infections." Oldspammer 09:23, 13 August 2006 (UTC)
[edit] Inhibited by Fluoride??
Every recommended use label and website I've seen for Chlorhexidine specifically states to use it after normal tooth cleaning. This usually means brushing with a fluoride toothpaste. Where does the "fact" that Chlorhexidine is deactivated by fluoride come from? Added {{fact}} tags to article --Storkk 12:33, 20 August 2006 (UTC)
It appears an incorrect interpretation of the label on a number of chlorhexidine mouthwashes. The labels usually say something like "some ingredients in toothpaste may stop this product from working properly". Indeed, the concentration of fluoride in toothpaste is so small that fluoride inactivation seems relatively implausible. The problem appears to be the fact that chlorhexidine is a cationic compound and is incompatible with a number of anions. The major culprits appear to be detergents such as sodium lauryl sulfate which is used in most toothpastes. ChumpusRex 22:20, 21 August 2006 (UTC)
