Chemokine receptor

From Wikipedia, the free encyclopedia

Typical structure of a chemokine receptor, with seven transmembrane domains and a characteristic "DRY" motif in the second intracellular domain. Chemokine receptors are usually linked to a G-protein through which they signal.

Chemokine receptors are G-protein-linked 7-transmembrane receptors expressed on the surfaces of certain cells.

They interact with small extracellular protein ligands known as chemokines. Following interaction with their specific ligands, chemokine receptors trigger a flux in intracellular calcium (Ca²⁺) ions (calcium signaling), which generates a chemotactic response of that cell, thus trafficking the cell to a desired location within the organism. These chemokine receptors are divided into different families according to which family of chemokines they bind (CC, CXC, C, or CX3C).

[edit] Families

• CXC chemokine receptors (seven members)

• CC chemokine receptors (ten/eleven members)

• C chemokine receptors (one member, XCR1)

• CX₃C chemokine receptors (one member, CX3CR1)

[edit] Further reading

• Murphy, International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature, Pharmacological Reviews, 2002, 54:227-229.

• Murphy et al., International union of pharmacology. XXII. Nomenclature for chemokine receptors, Pharmacological Reviews, 2002, 52:145-76.

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[edit] External links

• IUPHAR RECEPTOR DATABASE
• The Cytokine Receptor Database