Chaperonopathy

From Wikipedia, the free encyclopedia

Chaperonopathy is a pathological condition typified by a defect in a chaperone. A genetic chaperonopathy involves a structural defect in a molecular chaperone due to a genetic (hereditary) factor, such as a mutation in the gene that codes for the defective chaperone. An acquired chaperonopathy is due to a structural defect in a molecular chaperone acquired during the life of a cell or individual and is not hereditary, i.e., it is not passed on to the offspring. Other types of chaperonopathies occur in which no structural defect is observed but the levels of chaperones in cells and/or biological fluids (e.g., blood) are either diminished or elevated.

Bibliography

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