Cetylpyridinium chloride
From Wikipedia, the free encyclopedia
Cetylpyridinium chloride (CPC) is a cationic quaternary ammonium compound in some types of mouthwash such as Crest Pro-Health®, Scope®, Reach ACT®, Cēpacol®, Viadent®, Oasis®, Dr. Fresh®, swish®, BreathRX®, Septolete Plus®, and BetaCell®, toothpastes such as Crest Sensitivity® and Crest Plus Scope®, Cēpacol® lozenges and throat sprays, anti-snore throat sprays (Breathe Right®, Rite Aid, CVS, Walgreens, etc., brands), Oasis® moisturizing mouth spray, BreathRX® breath spray, and SinoFresh® and Ayr No-Drip Sinus® nasal sprays. It is an antiseptic that kills bacteria and other microorganisms. It has been shown to be effective in preventing dental plaque and reducing gingivitis. It has also been used as an ingredient in certain pesticides. However, this ingredient has also been shown (according to WebMD,[1] eMedicine,[2] and Amazon.com[3] and Drugstore.com reviews of Crest Pro-Health® rinse product) to cause brown stains between the teeth.
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[edit] Synonyms
Cetylpyridinium chloride is also known as 1-palmitylpyridinium chloride, C16-alkylpyridinium chloride, 1-hexadecylpyridinium chloride, acetoquat CPC, aktivex, ammonyx CPC, cecure, ceepryn chloride, cepacol, ceprim, cepacol chloride, cetafilm, cetamium, dobendan, halset, ipanol, medilave, mercocet, merothol, pionin B, pristacin, pyrisept.
[edit] Physical and chemical properties
Cetylpyridinium chloride has the molecular formula C21H38NCl and is a white powder at room temperature. It has a melting point of 77 degrees when anhydrous or 80-83 degrees in its monohydrate form. It is insoluble in acetone, acetic acid, or ethanol but is otherwise freely soluble. It has a pyridine-like odor. It is combustible. Concentrated solutions are destructive to mucous membranes. It is very toxic when inhaled.
Its CAS number is [] and its SMILES structure is CCCCCCCCCCCCCCCC[n+]1ccccc1.[Cl-]. The CAS number for the monohydrate is [].
In some products, cetylpyridinium bromide is used instead. Its properties are virtually identical.
[edit] Toxicology and Pharmacology
The LD50 in rats is 200 mg/kg.
