Central giant cell granuloma

From Wikipedia, the free encyclopedia

Central giant cell granuloma (CGCG) is a benign condition of the jaws. It is twice as likely to affect women and is more likely to occur 20 - 40 year old people. Central giant cell granulomas are more common in the mandible and often crosses the midline.

Detailed information -

CGCG is a benign intraosseous lesion found in the anterior of the maxilla and the mandible in you a people (before age 20). It is characterized by large lesions that expand the cortical plate and can reabsorb roots and move teeth. It is composed of mulitnucleated giant cells. It has a slight predilection for females.

Radiographically it appears as multilocular radiolucencies of bone.

There are two types of CGCG's, Non-aggressive and aggressive. The former has a slow rate of growth and thus less likely to absorb roots and perforate the cortical plate. The aggressive form has rapid growth and thus is much more likely to absorb roots and perforate the cortical plate. It also has a high rate for recurrence and can be painful and cause paresthesia.

Differential diagnosis to include: OKC, ameloblastoma, odontogentic myxoma, hemangioma, central odontogenic fibroma, hyperparathyroid tumor, and cherubism.