Cefotaxime

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Chemical structure of Cefotaxime
Cefotaxime
Systematic (IUPAC) name
(6R,7R,Z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-
2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]
oct-2-ene-2-carboxylic acid
Identifiers
CAS number 63527-52-6
ATC code J01DD01
PubChem 456256
DrugBank APRD00854
Chemical data
Formula C16H17N5O7S2 
Mol. mass 455.47 g/mol
Pharmacokinetic data
Bioavailability n/a
Metabolism Hepatic
Half life 0.8–1.4 hours
Excretion 50–85% renal
Therapeutic considerations
Pregnancy cat.

B1(AU) B(US)

Legal status

Prescription Only (S4)(AU)

Routes Intravenous

Cefotaxime (INN) (IPA: [kɛfəˈtæksim, sɛfə-]) is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).

[edit] Clinical use

Main article: Cephalosporin

[edit] Chemistry

The syn-configuration of the methoxyimino moiety confers stability to β-lactamase enzymes produced by many Gram-negative bacteria. Such stability to β-lactamases increases the activity of cefotaxime against otherwise resistant Gram-negative organisms.


[edit] External links

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