CD8
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CD8a molecule
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Identifiers | |
Symbol | CD8A CD8 |
HUGO | 1706 |
Entrez | 925 |
OMIM | 186910 |
RefSeq | NM_001768 |
UniProt | P01732 |
Other data | |
Locus | Chr. 2 p12 |
CD8b molecule
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Identifiers | |
Symbol | CD8B CD8B1 |
HUGO | 1707 |
Entrez | 926 |
OMIM | 186730 |
RefSeq | NM_172099 |
UniProt | P10966 |
Other data | |
Locus | Chr. 2 p12 |
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein which serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein.[1] It is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells. To function, CD8 forms a dimer, consisting of a pair of CD8 chains. The most common form of CD8 is composed of an CD8-α and CD8-β chain, both members of the immunoglobulin superfamily with an immunoglobulin variable (IgV)-like extracellular domain connected to the membrane by a thin stalk, and an intracellular tail. Less common homodimers of the CD8-α chain are also expressed on some cells. The extracellular IgV-like domain of CD8-α interacts with to the α3 portion of the Class I MHC molecule.[2] This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen-specific activation. Cytotoxic T cells with CD8 surface protein are called CD8+ T cells.
[edit] References
- ^ Gao G, Jakobsen B (2000). "Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor". Immunol Today 21 (12): 630-6. PMID 11114424.
- ^ Devine L, Sun J, Barr M, Kavathas P (1999). "Orientation of the Ig domains of CD8 alpha beta relative to MHC class I". J Immunol 162 (2): 846-51. PMID 9916707.
The antigen receptor: TCR | TCRα | TCRβ | TCRγ | TCRδ
Accessory molecules: CD3 | CD3γ | CD3δ | CD3ε | ζ-chain (also called CD3ζ and TCRζ)
Co-receptors: CD8 (with two glycoprotein chains CD8α and CD8β) | CD4
Ligands: MHC (MHC class I and MHC class II)
Antigen receptor (B-cell receptor, T cell receptor) - Complement - Fc (FcεRI, FcεRII, FcγRI, FcγRII, FcγRIII, FcαRI, Fcα/μR, Neonatal) - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like receptor - Lymphocyte homing receptor (CD44, L-selectin, Integrin alpha4beta1, LFA-1) - Pattern recognition/Toll-like (TLR 2, TLR 3) - Scavenger
Cytokine receptors: Type I (IL-2, IL-3) - Type II - Glycoprotein 130 - Chemokine receptor - TGF-beta receptors
CD1 - CD1d - CD2 - CD3 - CD4 - CD8 - CD11a - CD11b - CD11c - CD14 - CD15 - CD16 - CD18 - CD19 - CD20 - CD22 - CD23 - CD24 - CD25 - CD26 - CD28 - CD29 - CD30 - CD31 - CD32 - CD33 - CD34 - CD35 - CD36 - CD38 - CD40 - CD43 - CD44 - CD45 - CD46 - CD49a - CD49b - CD49c - CD49d - CD52 - CD54 - CD55 - CD56 - CD59 - CD62E - CD62L - CD62P - CD64 - CD66e - CD68 - CD70 - CD71 - CD72 - CD79 - CD80 - CD86 - CD88 - CD89 - CD90 - CD94 - CD95 - CD98 - CD106 - CD117 - CD122 - CD130 - CD132 - CD133 - CD134 - CD141 - CD142 - CD143 - CD146 - CD147 - CD152 - CD153 - CD154 - CD155 - CD164 - CD184 - CD169 - CD206 - CD209 - CD278