CD79

CD79a molecule, immunoglobulin-associated alpha
Identifiers
Symbol	CD79A IGA
HUGO	1698
Entrez	973
OMIM	112205
RefSeq	NM_001783
UniProt	P11912
Other data
Locus	Chr. 19 q13.2

CD79b molecule, immunoglobulin-associated beta
Identifiers
Symbol	CD79B IGB
HUGO	1699
Entrez	974
OMIM	147245
RefSeq	NM_021602
UniProt	P40259
Other data
Locus	Chr. 17 q23

CD79 is a transmembrane protein that forms a complex with the B-cell receptor (BCR) and generates a signal following recognition of antigen by the BCR. CD79 is composed of two distinct chains called CD79a and CD79b (formerly known as Ig-alpha and Ig-beta); these form a heterodimer on the surface of a B cell stabilized by disulphide bonding.^[1] CD79a and CD79b are both members of the immunoglobulin superfamily. Human CD79a is encoded by the mb-1 gene that is located on chromosome 19, and CD79b is encoded by the B29 gene that located on chromosome 17.^[1]^[2] Both CD79 chains contain an immunoreceptor tyrosine-based activation motif (ITAM) in their intracellular tails that they use to propogate a signal in a B cell, in a similar manner to CD3 generated signal tranduction observed during T cell receptor activation on T cells.^[3]

[edit] References

^ ^a ^b Chu P, Arber D (2001). "CD79: a review". Appl Immunohistochem Mol Morphol 9 (2): 97-106. PMID 11396639.
^ Van Noesel C, Brouns G, van Schijndel G, Bende R, Mason D, Borst J, van Lier R (1992). "Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers". J Exp Med 175 (6): 1511-9. PMID 1375264.
^ Müller B, Cooper L, Terhorst C (1995). "Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29)". Immunol Lett 44 (2-3): 97-103. PMID 7541024.