CD2

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The protein structure of CD2
Cluster of differentiation 2
Identifiers
Symbol	CD2 SRBC
HUGO	1639
Entrez	914
OMIM	186990
RefSeq	NM_001767
UniProt	P06729
PDB	1HNF
Other data
Locus	Chr. 1 p13

CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells.^[1] It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor.^[2] In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells.^[3] Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.^[3]

[edit] References

^ Wilkins A, Yang W, Yang J (2003). "Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design". Curr Protein Pept Sci 4 (5): 367-73. PMID 14529530.
^ Uniprot database entry for CD2 (accession number P06729)
^ ^a ^b Yang J, Ye Y, Carroll A, Yang W, Lee H (2001). "Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation". Curr Protein Pept Sci 2 (1): 1-17. PMID 12369898.