CD20

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membrane-spanning 4-domains, subfamily A, member 1
Identifiers
Symbol	MS4A1 CD20
HUGO	7315
Entrez	931
OMIM	112210
RefSeq	NM_152866
UniProt	P11836
Other data
Locus	Chr. 11 q13

CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells.

[edit] Function

The protein has no known natural ligand and its function is unclear. It is suspected that it acts as a calcium channel in the cell membrane. It is also found on B-cell lymphomas, hairy cell leukemia, and B-cell chronic lymphocytic leukemia.

[edit] Clinical significance

It is the target of the monoclonal antibodies rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of Non-Hodgkin Lymphoma.