CD19

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CD19
Identifiers
Symbol	CD19 CD19 molecule
HUGO	1633
Entrez	930
OMIM	107265
RefSeq	NM_001770
UniProt	P15391
Other data
Locus	Chr. 16 p11.2

CD19 is a cell-surface molecule typically found on the B cell. It has a molecular weight of >120 kDa.

It is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells.

It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81.

Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated which leads to binding by Src-family kinases and recruitment of PI-3 kinase.

[edit] Source

• Kindt, Thomas J., et al. Kuby Immunology. New York: W.H. Freeman and Company, 2007.