Caspase-9
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caspase 9, apoptosis-related cysteine peptidase
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| Identifiers | |
| Symbol | CASP9 |
| HUGO | 1511 |
| Entrez | 842 |
| OMIM | 602234 |
| RefSeq | NM_032996 |
| UniProt | P55211 |
| Other data | |
| Locus | Chr. 1 p36.3-1p36.1 |
Caspase-9 is an initiator caspase.[1]
The aspartic acid specific protease caspase-9 has been linked to the mitochondrial death pathway. It is activated during programed cell death (apoptosis). Induction of stress signalling pathways JNK/SAPK causes release of cytochrome c from mitochondria and activation of apaf-1 (apoptosome), which in turn cleaves the pro-enzyme of caspase-9 into the active form.
Once intiated caspase-9 goes on to cleave procaspase-3 & procaspase-7 and which cleave several cellular targets, including poly ADP ribose polymerase.
[edit] References
[edit] External links
- Lei K, Nimnual A, Zong W, Kennedy N, Flavell R, Thompson C, Bar-Sagi D, Davis R (2002). "The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase.". Mol Cell Biol 22 (13): 4929-42. PMID 12052897.
- Earnshaw W, Martins L, Kaufmann S. "Mammalian caspases: structure, activation, substrates, and functions during apoptosis.". Annu Rev Biochem 68: 383-424. PMID 10872455.
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