Casein kinase 2
From Wikipedia, the free encyclopedia
The Casein kinase 2 is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.
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casein kinase 2, alpha 1 polypeptide
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| Identifiers | |
| Symbol(s) | CSNK2A1 |
| Entrez | 1457 |
| OMIM | 115440 |
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casein kinase 2, alpha prime polypeptide
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| Identifiers | |
| Symbol(s) | CSNK2A2 |
| Entrez | 1459 |
| OMIM | 115442 |
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casein kinase 2, beta polypeptide
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| Identifiers | |
| Symbol(s) | CSNK2B |
| Entrez | 1460 |
| OMIM | 115441 |
Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation[1]. A Pertussis toxin-sensitive G protein and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.
Mice that lack casein kinase 2 alpha prime have a defect in the morphlogy of developing sperm [2]
[edit] See also
- Casein kinase 1 - a distinct protein kinase family
[edit] References
- ^ Y. Gao and H. Y. Wang (2006) "Casein kinase 2 is activated and essential for wnt/beta-catenin signaling" in Journal of Biological Chemistry Entrez PubMed 16672224
- ^ X. Xu, P. Toselli, L. Russell and D. Seldin (1999) "Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit" in Nature Genetics Volume 23, pages 118-121. Entrez PubMed 10471512
Key concepts: Ligand - Receptor (Transmembrane, Intracellular) - Transcription factor (General, Preinitiation complex, TFIID, TFIIH) - Cell signaling networks - Signal transduction - Adaptor protein - Apoptosis - Second messenger system (Ca2+ signaling, Lipid signaling)
Paracrine - Autocrine - Juxtacrine - Neurotransmitters - Endocrine (Neuroendocrine)
