Calcium-binding protein
From Wikipedia, the free encyclopedia
Calcium-binding proteins are proteins that participate in calcium cell signalling pathways by binding to Ca2+.
The most ubiquitous Ca2+-sensing protein, found in all eukaryotic organisms including yeasts, is calmodulin.
Intracellular storage and release of Ca2+ from the sarcoplasmic reticulum is associated with the high-capacity, low-affinity calcium-binding protein, calsequestrin.[1]
With their role in signal transduction, calcium-binding proteins contribute to all aspects of the cell's functioning, from homeostasis to learning and memory.
For example, the neuron-specific calexcitin has been found to have an excitatory effect on neurons, and interacts with proteins that control the firing state of neurons, such as the the voltage-dependent potassium channel.[2]
[edit] See also
- Vitamin D-dependent calcium-binding protein
- Wikipedia:MeSH_D12.776#MeSH_D12.776.157.125_---_calcium-binding_proteins
[edit] References
- ^ Siegel, George (Ed.). Basic neurochemistry : molecular, cellular and medical aspects. Lippincott Williams and Wilkins / 1999 ISBN 0-397-51820-X
- ^ Nelson T, Cavallaro S, Yi C, McPhie D, Schreurs B, Gusev P, Favit A, Zohar O, Kim J, Beushausen S, Ascoli G, Olds J, Neve R, Alkon D (1996). "Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability". Proc Natl Acad Sci U S A 93 (24): 13808-13. PMID 8943017.
[edit] External links
Acyl carrier protein - Adaptor protein - F-box protein - GTP-binding protein - Light-harvesting complex - Membrane transport protein
Calcium-binding protein - Calmodulin-binding proteins - Ceruloplasmin - Cholesterylester transfer protein - Iron-binding proteins - Retinol binding protein - Transferrin receptor - Transcobalamins
Follistatin - Growth hormone binding protein - Insulin-like growth factor binding protein - Neurophysins (Neurophysin I, II)
Sex hormone binding globulin/Androgen binding protein - Transcortin - Thyroxine-binding globulin - Transthyretin
Annexin (A1, A2, A5) - Vitamin D-dependent calcium-binding protein/Calbindin - Calexcitin - Calsequestrin - Osteocalcin - Osteonectin - S-100 - Synaptotagmin - Troponin C
Intracellular calcium-sensing proteins: Calmodulin - Calnexin - Calreticulin - Gelsolin - neuronal (Hippocalcin, Neurocalcin, Recoverin)
