Calcineurin

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protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
Identifiers
Symbol	PPP3CA CALN, CALNA
HUGO	9314
Entrez	5530
OMIM	114105
RefSeq	NM_000944
UniProt	Q08209
Other data
EC number	3.1.3.16
Locus	Chr. 4 q21-q24

Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 2B (PP2B). Calcineurin is responsible for activating the transcription of interleukin 2 (IL-2), that stimulates the growth and differentiation of T cell response. In immunosuppressive therapy it is inhibited by cyclosporin, pimecrolimus (Elidel) and tacrolimus (FK506) - these drugs are known as calcineurin inhibitors. Calcineurin dephosphorylates NFATc, a transcription factor that can then go into the nucleus and turn on genes involved in IL-2 synthesis.

1 Mechanism of action
2 Research into Diabetes
3 References
4 External links

[edit] Mechanism of action

When T-helper cell's receptor interacts with an antigen, the intracellular concentration of calcium in the cell rises. This increase activates calcineurin. Calcineurin induces different transcription factors that are important in the transcription of IL-2 genes. IL-2 activates T-helper lymphocytes and induces the production of other cytokines. In this way, it governs the action of cytotoxic lymphocytes and NK cells. The amount of IL-2 being produced by the T-helper cells is believed to influence the extent of the immune response significantly.

[edit] Research into Diabetes

Scientist believe that calcineurin might prove to be one of the two keys, along with NFAT, in improving the function of diabetics' pancreatic beta cells.^[1]^[2]

Calcineurin/Nfat signaling is required for perinatal lung maturation and function:^[3]