Brushfield spots

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Brushfield spots are small white spots on the periphery of the iris in the human eye due to aggregation of a normal iris element (connective tissue). These spots are normal in children but are also a feature of Down syndrome. They are named after the physician, Thomas Brushfield, who first described them in 1924.

They are focal areas of stromal hyperplasia, surrounded by relative hypoplasia and are more common in patients with lightly pigmented irises.