Bone morphogenetic protein 2

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Bone morphogenetic protein 2
Model of Bone morphogenetic protein 2
Other names:	(BMP2A)
Genetic data
Locus:	Chr. 20 p12
Gene code:	HUGO code:BMP2
Protein Structure/Function
Structure:	Molecular structure
Functions:	cell signalling, cell differentiation
Domains:	TGFβ
Other
Taxa expressing:	Homo Sapiens; homologs :many metazoan phyla
Cell types:	many
Subcellular localization:	extracellular
Molecular interactions:	GREM2, SOSTDC1
Database Links
Entrez:	650
OMIM:	112261
RefSeq:	NM_001200
UniProt:	P12643

Bone morphogenetic protein 2 or BMP-2 is a protein that belongs to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the Hedgehog pathway, TGF-beta signaling pathway, and the Cytokine-cytokine receptor interaction. It is involved also in cardiac cell differentiation and epithelial to mesenchymal transition.

BMP-2 and BMP-7 are osteogenic BMPs: they have been demonstrated to potently induce osteoblast differentiation in a variety of cell types.

[edit] Medical Uses

Bone morphogenetic protein 2 has been shown to stimulate the production of bone and recombinant human protein (rhBMP-2) is currently available in for orthopaedic usage in the United States. Implantation of BMP-2 in a collagen sponge induces new bone formation and can be used for the treatment of bony defects, delayed union, and non-union.