Bone morphogenetic protein 15
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| Bone Morphogentic Protein 15 | |
|---|---|
| Other names: | Growth differentiation factor 9B (GDF9b) |
| Genetic data | |
| Locus: | Chr. X p11.2 |
| Gene code: | HUGO code: BMP15 |
| Protein Structure/Function | |
| Functions: | cell signalling |
| Domains: | TGFβ |
| Other | |
| Taxa expressing: | many metazoan phyla |
| Cell types: | mesenchymal |
| Medical/Biotechnological data | |
| Diseases: | ovarian disgenesis 2 |
| Database Links | |
| Entrez: | 9210 |
| OMIM: | 300247 |
| RefSeq: | NM_005448 |
| UniProt: | O95972 |
Bone morphogenetic protein 15 is a member of the TGF-β superfamily of proteins. It is a paracrine signalling molecule involved in oocyte and follicular] development. Using Northern blot analysis, BMP15 has been shown to be exclusively expressed in the ovaries. It can be a homodimer or heterodimer.
TGF beta superfamily of ligands:
Activin A and B - Anti-müllerian hormone - Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) - Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF9, GDF10, GDF11, GDF15) - Inhibin A and B - Myostatin - Nodal - TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Type II receptors:ACVR2A - ACVR2B - AMHR2 - BMPR2 - TGFBR2 - TGFBR3
Type I receptors: ACVR1A - ACVR1B - ACVR1C - ACVRL1 - BMPR1A - BMPR1B - TGFBR1
Signal transducers/SMAD: R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors: Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
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