Bone morphogenetic protein 1

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Bone morphogenetic protein 1
Other names:	procollagen C-endopeptidase (PCOLC)
Genetic data
Gene code:	HUGO code:BMP1
Protein Structure/Function
Functions:	cell signalling, cell differentiation,cartilage condensation, proteolysis, ossification
Domains:	ZnMc,CUB,EGFCA
Other
Taxa expressing:	Homo sapiens; homologs: many metazoan phyla
Cell types:	Skin, Brain, Placenta, Liver, Pancreas, Muscle
Subcellular localization:	extracellular
Covalent modifications:	Glycosylation

Bone morphogenetic protein 1 (BMP1) is a protein that belongs to the peptidase M12A family of proteins. It induces bone and cartilage development. It is unlike other bone morphogenetic proteins since it does not belong to the TGFβ superfamily of proteins. It was initially discovered to work like other bone morphogenetic proteins by inducing bone and cartilage development. It however, is a metalloprotease that cleaves the C-terminus of procollagen I, II and III. It has an astacin-like protease domain.

It has been shown to cleave laminin 5 and is localized in the basal epithelial layer of bovine skin.

There are seven isoforms of the enzyme created by alternate splicing.