Boldenone
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Boldenone
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| Systematic (IUPAC) name | |
| 1,4-androstadiene-3-one-17β-ol | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C19H26O2 |
| Mol. mass | 286.409 g/mol |
| Physical data | |
| Melt. point | 165 °C (329 °F) |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Boldenone (1,4-androstadiene-3-one-17β-ol, available as the undecylenate ester), also known under the trade names Equipoise, Ganabol, Equigan and Ultragan, is an anabolic steroid developed for veterinary use, mostly for treatment of horses. It is not indicated for use in humans in the US and is only available through veterinary clinics.
[edit] Use in doping
The activity of boldenone is mainly anabolic, with a low androgenic potency. It has a very long half-life, with minimal blood levels present up to 8 weeks after discontinued use.
Boldenone will increase nitrogen retention, protein synthesis, increases appetite and stimulates the release of erythropoietin in the kidneys. The drug is commonly used in doping within bodybuilding, even though this use is illegal. If intended to assist in bodybuilding, the drug is taken as part of a steroid stack of other anabolic steroids, usually with a potent androgen like testosterone as the 'base' of the stack.
Common bodybuilding doses range between 200 mg to 400 mg/week but could be as high as 800 mg/week.
Boldenone has a low rate of aromatization (about 50% of Testosterone), which means it does not convert to estrogen easily and does not cause very much water retention. Many Bodybuilders will find that it is a good replacement drug for Nandrolone.
Boldenone is among the substances banned by Major League Baseball, as well as most other major athletic organizations.
It is a poor drug of choice for any athlete who will be subject to a blood test due to its long metabolic half-life. Trace amounts of the drug can easily be detected for months after discontinued use.
[edit] Boldenone use in mixed martial arts
Some mixed martial arts (MMA) fighters from the UFC and PRIDE Fighting Championships, have also tested positive for the banned substance.[citation needed] After the World Extreme Cagefighting show on January 20, 2006 some fighters also tested positive for Boldenone.[citation needed]
[edit] Side effects
Although commonly compared to nandrolone, boldenone lacks progesterone receptor interaction and all the associated progestinic side effects. Boldenone can, however, produce mild androgenic side effects. Oily skin, acne, increased aggression and hair loss are all possible with this compound but rare. Boldenone does reduce to a more potent androgen dihydroboldenone via the 5alpha-reductase enzyme (analogous to the conversion of testosterone to dihydrotestosterone DHT), however its affinity for this interaction in the human body is low to nonexistent. Suppression of the HPTA, water retention, possible increase in acne and possible conversion to estrogen, high blood pressure are all side effects associated with Boldenone. Boldenone is also known to cause anxiety and flu like symptoms which manifest themselves most acutely in short ester versions like: acetate, and propionate (almost unusable), but which are also present in the enanthate, cypionate, and undecyclenate forms.
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