Talk:Biopharmaceutical

[edit] To be added:

This list is incomplete, please discuss and add more.

• Biopharmaceutical development (see: drug development) and approval process (preferably fow-sheet):
  • Rational drug design and combinatorial chemistry approach (in brief)
  • Patenting of biopharmaceuticals (USPTO, EPO, etc)

• Classification:
  • Nucleic acid therapeutics (Gene therapy, antisense technology, etc.)
  • Recombinant proteins: Subunit vaccine
  • Antibody based therapeutics: monoclonal antibodies, etc.

• Delivery (see: drug delivery):
  • Oral, pulmonary, nasal, transmusocal and transdermal delivery systems.

• Uses:
  • ...
  • Focus: Development of AIDS vaccine (see: HIV vaccine).
  • Focus: Gene therapy and cancer (also AIDS).

• Large scale production:
  • Details of platforms i.e. mammalian cell, yeast cells, insect cell, plant cell culture and whole-plants.
  • Their relative advantages and disadvantages (preferably in tablular form).
  • to include biological production of hormones, interferons, etc from genetically engineered cells (pathways, sources, cell line).
  • Downstream processing (filtration, etc)

• Others:
  • Proteomics in biopharmacetical drug development and diagnosis of disease.
  • Enzymes in clinical diagnostics (clinical enzymology) - biosensors - microanalysis kit development.

• Purity, efficacy, potency, safety, cost, etc.:
  • Regulation by authorities like US FDA, European Commission, etc.

• Ethics: public concern in
  • Gene therapy (in vivo): human germ line
  • Genetic modification of plants and animals for our benefit
  • Cost vs. degree of action

• Acceptance by society:
  • Factors involved...

• Business of biopharmaceuticals:
  • Industry statistics (sales, etc.)
  • Companies (Amgen, Biogen, Genentech, Boehringer Ingelheim, etc.)

• ...
• ...

• References:
  • ...

• External links:
  • Please add