Belatacept
From Wikipedia, the free encyclopedia
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Belatacept
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| Source | ? |
| Target | CTLA 4 |
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| CAS number | ? |
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| Formula | ? |
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| Bioavailability | ? |
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Belatacept is a fusion protein composed of the Fc fragment of a human IgG1 immunoglobulin linked to the extracellular domain of CTLA-4 (http://www.healthvalue.net/ctlaigenglish.html), which is a molecule crucial for T-cell costimulation, selectively blocking the process of T-cell activation. It was developed by Bristol-Myers-Squibb. It differs from abatacept (Orencia) by only 2 amino acids.
It is intended to provide extended graft survival while limiting the toxicity generated by standard immune suppressing regimens, such as calcineurin inhibitors.
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