Bcl-2-associated death promoter

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BCL2-antagonist of cell death
Identifiers
Symbol BAD
HUGO 936
Entrez 572
OMIM 603167
RefSeq NM_032989
UniProt Q92934
Other data
Locus Chr. 11 q13.1

The Bcl-2-associated death promoter (BAD) protein is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis. It does not contain a C-terminal transmembrane domain for outer mitochondrial membrane and nuclear envelope targeting, unlike most other members of the Bcl-2 family [1]. Pro-apoptotic activation of this protein occurs through phosphorylation[2]. After activation, it is able to form a heterodimer with anti-apoptotic proteins and prevent them from stopping apoptosis.

BAD is a member of the BH3-only family [3], a subfamily of the Bcl-2 family.

[edit] See also

[edit] References

  1. ^ Sheau Yu Hsu, et al. (1997). "Interference of BAD (Bcl-xL/Bcl-2-Associated Death Promoter)-Induced Apoptosis in Mammalian Cells by 14–3-3 Isoforms and P11". Molecular Endocrinology 11 (12). 
  2. ^ Entrez Gene entry for BAD. NCBI. Retrieved on [[2006-12-19]].
  3. ^ Adachi M. and Imai K. (2002). "The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2". Cell death and differentiation 9 (11). 

[edit] External links

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