BAMBI
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BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
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| Identifiers | |
| Symbol | BAMBI |
| HUGO | 30251 |
| Entrez | 25805 |
| OMIM | 604444 |
| RefSeq | NM_012342 |
| UniProt | Q13145 |
| Other data | |
| Locus | Chr. 10 p12.3-11.2 |
Bone and Activin membrane bound inhibitor (BAMBI), has a similar extracellular domain as type I receptors in the TGF beta signaling pathway. It lacks an intracellular serine/threonine protein kinase domain and hence is a pseudoreceptor.
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TGF beta superfamily of ligands:
Activin A and B - Anti-müllerian hormone - Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) - Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF9, GDF10, GDF11, GDF15) - Inhibin A and B - Myostatin - Nodal - TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Type II receptors:ACVR2A - ACVR2B - AMHR2 - BMPR2 - TGFBR2 - TGFBR3
Type I receptors: ACVR1A - ACVR1B - ACVR1C - ACVRL1 - BMPR1A - BMPR1B - TGFBR1
Signal transducers/SMAD: R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors: Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
