Avidin

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Avidin is a protein found in egg white that binds with biotin, found in egg yolk. In biochemical applications, streptavidin, which binds very tightly to Biotin, is often used in place of avidin.

[edit] Relationship between avidin and biotin

Avidin is a glycoprotein that has a very strong affinity for biotin with a kD (dissociation constant) approximate to 10-15 M-1[1], the highest known between any ligand and a protein, and, as such, prevents biotin absorption in the gastrointestinal tract. Avidin is a tetrameric protein attaching four molecules of biotin per tetramer.


Avidin's affinity for biotin is exploited in both ELISPOT and ELISA assays.

[edit] References

  1. ↑  Bayer, Ed: "The Avidin-Biotin Complex", Dept. of Biological Chemistry, Weizmann Institute of Science, Israel


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