Auranofin
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Auranofin
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| Systematic (IUPAC) name | |
| gold(+1) cation; 3,4,5-triacetyloxy-6- (acetyloxymethyl) oxane-2-thiolate; triethylphosphanium | |
| Identifiers | |
| CAS number | |
| ATC code | M01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C20H35AuO9PS+1 |
| Mol. mass | 679.493 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Auranofin is a organogold compound classified by the World Health Organization as an antirheumatic agent.
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[edit] External links
- MedlinePlus DrugInfo medmaster-a685038
- Cochrane review - "Auranofin versus placebo in rheumatoid arthritis"
- Jeon K, Byun M, Jue D (2003). "Gold compound auranofin inhibits IkappaB kinase (IKK) by modifying Cys-179 of IKKbeta subunit.". Exp Mol Med 35 (2): 61-6. PMID 12754408.
- Kim I, Jin J, Lee I, Park S (2004). "Auranofin induces apoptosis and when combined with retinoic acid enhances differentiation of acute promyelocytic leukaemia cells in vitro.". Br J Pharmacol 142 (4): 749-55. PMID 15159275.
- Venardos K, Harrison G, Headrick J, Perkins A. "Auranofin increases apoptosis and ischaemia-reperfusion injury in the rat isolated heart.". Clin Exp Pharmacol Physiol 31 (5-6): 289-94. PMID 15191400.
- Hafejee A, Winhoven S, Coulson I (2004). "Jessner's lymphocytic infiltrate responding to oral auranofin.". J Dermatolog Treat 15 (5): 331-2. PMID 15370403.
- Rigobello M, Folda A, Baldoin M, Scutari G, Bindoli A (2005). "Effect of auranofin on the mitochondrial generation of hydrogen peroxide. Role of thioredoxin reductase.". Free Radic Res 39 (7): 687-95. PMID 16036347.
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