ATP-sensitive K+ channels
From Wikipedia, the free encyclopedia
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potassium inwardly-rectifying channel, subfamily J, member 11
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| Identifiers | |
| Symbol | KCNJ11 |
| HUGO | 6257 |
| Entrez | 3767 |
| OMIM | 600937 |
| RefSeq | NM_000525 |
| UniProt | Q14654 |
| Other data | |
| Locus | Chr. 11 p15.1 |
ATP-sensitive K+ channels is a type of potassium channel containing Kir6.2 and sulfonylurea receptors, along with additional subunits.[1]
It is usually closed in the heart; but when levels of ATP are reduced (as during ischemia), the channel opens.
[edit] See also
[edit] References
- ^ Stephan D, Winkler M, Kühner P, Russ U, Quast U (2006). "Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K(ATP) channels.". Diabetologia 49 (9): 2039-48. PMID 16865362.
[edit] External links
- "Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.". Pflugers Arch. PMID 17021801.
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