Arginine vasopressin receptor 1B

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Arginine vasopressin receptor 1B
Identifiers
Symbol	AVPR1B
HUGO	896
Entrez	553
OMIM	600264
RefSeq	NM_000707
UniProt	P47901
Other data
Locus	Chr. 1 q32

Arginine vasopressin receptor 1B (AVPR1B, vasopressin 3 receptor) is a protein that acts as receptor for arginine vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system.

Contents 1 Location 2 Research 3 Clinical significance 4 References

[edit] Location

AVPR1B was initially described as a novel vasopressin receptor located in the anterior pituitary, where it stimulates ACTH release. ^[1]

Subsequent studies have shown its presence in the brain as well.

[edit] Research

Inactivation of the Avpr1b in mice (knockout) produces mice with greatly reduced aggression.^[2] These mice also have a reduced ability to recognize recently investigated mice. There is evidence that social motivation or awareness is reduced in these mice.

The AVPR1B antagonist, SSR149415, has been shown to have anti-aggressive actions in hamsters and anti-depressant- and anxiety (anxiolytic)-like behaviors in rats.^[3]

[edit] Clinical significance

AVPR1B is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome.

[edit] References