Talk:ARF (G-Protein)

From Wikipedia, the free encyclopedia

	MCB Portal This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The current monthly improvement drive is Signal transduction.
Start	This article has been rated as start-Class on the assessment scale.
Mid	This article is on a subject of mid-importance within molecular and cellular biology.
Article Grading: The article has been rated for quality and/or importance but has no comments yet. If appropriate, please review the article and then leave comments here to identify the strengths and weaknesses of the article and what work it will need.

The article makes it sound as though the vesicle coat stays intact until ARF, upon activation of its GTPase activity, hydrolyses GTP at the target membrane. I'm not sure this is true. Can someone cite sources?

I believe this is indeed the case. When I wrote this article i was primarily referencing Molecular Biology of the Cell by Albert. I'll have another look! Snellios 22:37, 9 February 2007 (UTC)

Quoting from Lodish: "Small GTP-binding proteins (ARF or Sar1) belonging to the GTPase superfamily control polymerization of coat proteins, the initial step in vesicle budding. After vesicles are released from the donor membrane, hydrolysis of GTP bound to ARF or Sar1 triggers disassembly of the vesicle coats." There actually is a GTPase that is involved with recognizing and tethering towards the target membrane, it's called Rab. --84.172.250.196 22:13, 10 February 2007 (UTC)