Apraclonidine

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Apraclonidine
Systematic (IUPAC) name
2,6-dichloro-N- (4,5-dihydro-1H-imidazol-2-yl) benzene-1,4-diamine
Identifiers
CAS number	66711-21-5
ATC code	S01EA03
PubChem	2216
DrugBank	APRD00012
Chemical data
Formula	C9H10Cl2N4
Mol. mass	245.108 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	98.7%
Metabolism	?
Half life	8 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Apraclonidine is a sympathomimetic used in glaucoma therapy.

[edit] External links

• Chen P, Chen J, Lu D, Chen Y, Hsiao C (2006). "Comparing efficacies of 0.5% apraclonidine with 4% cocaine in the diagnosis of horner syndrome in pediatric patients.". J Ocul Pharmacol Ther 22 (3): 182-7. PMID 16808679. 
• Aslanides l, Tsiklis N, Ozkilic E, Coskunseven E, Pallikaris l, Jankov M (2006). "The effect of topical apraclonidine on subconjunctival hemorrhage and flap adherence in LASIK patients.". J Refract Surg 22 (6): 585-8. PMID 16805122. 
• Koc F, Kansu T, Kavuncu S, Firat E (2006). "Topical apraclonidine testing discloses pupillary sympathetic denervation in diabetic patients.". J Neuroophthalmol 26 (1): 25-9. PMID 16518162. 
• Garibaldi D, Hindman H, Grant M, Iliff N, Merbs S. "Effect of 0.5% apraclonidine on ptosis in Horner syndrome.". Ophthal Plast Reconstr Surg 22 (1): 53-5. PMID 16418668. 
• Onal S, Gozum N, Gucukoglu A. "Effect of apraclonidine versus dorzolamide on intraocular pressure after phacoemulsification.". Ophthalmic Surg Lasers Imaging 36 (6): 457-62. PMID 16355950. 

v • d • e Antiglaucoma preparations and miotics (S01E)
Sympathomimetics	Apraclonidine, Brimonidine, Clonidine, Dipivefrine, Epinephrine
Parasympathomimetics	Aceclidine, Acetylcholine, Carbachol, Demecarium, Echothiophate, Fluostigmine, Neostigmine, Paraoxon, Physostigmine, Pilocarpine
Carbonic anhydrase inhibitors	Acetazolamide, Brinzolamide, Diclofenamide, Dorzolamide, Methazolamide
Beta blocking agents	Befunolol, Betaxolol, Carteolol, Levobunolol, Metipranolol, Timolol
Prostaglandin analogues	Bimatoprost, Latanoprost, Travoprost, Unoprostone
Other agents	Dapiprazole, Guanethidine