Aphidicolin
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Aphidicolin is defined as a tetracyclic diterpene antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S-phase. It is a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses and an Apoptosis inducer in HeLa cells.
[edit] Further reading
Expression of aphidicolin-induced fragile sites and their relationship between genetic susceptibility in breast cancer, ovarian cancer, and non-small-cell lung cancer patients
[edit] External links
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