Talk:Angiogenesis
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Citation This page was cited by Harvard Journal of Law & Technology |
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[edit] Proper Terminology and Mechanisms
I am studying microvasculature remodeling as a result of exercise at the University of Virginia and noticed that this page was lacking in general mechanisms of angiogenesis. Angiogenesis refers only to the changes in capillaries, just a terminology issue. I have outlined many of the chemical mechanisms relating to angiogenesis. Xwingjedi14 06:50, 14 December 2005 (UTC)
[edit] How important is an increased tumor cell mutation rate?
There are some good examples of increased mutation rate in certain cancers, but I am not sure that it has been established that a high mutation rate is required for angiogenesis.
The article Genetic instability and the evolution of angiogenic tumor cell lines (review) claims support from mathematical models for the idea that faster mutation is important.
Other articles such as Angiogenesis and the role of epigenetics in metastasis seem to point towards a need to investigate a combination of mutational and epigenetic mechanisms.
A recent review article Genetic hits and mutation rate in colorectal tumorigenesis: versatility of Knudson's theory and implications for cancer prevention says: "The challenges ahead are to define the number of genetic hits necessary for conversion of a normal cell into a cancer cell and to determine whether the observed increase in the mutation rate (mutator phenotype) is required."
Is there really any data on the role of tumor cell mutation rate in angiogenesis?
Removed reference to evolution at cellular level. This is impossible (how are the selected changes to be passed to the next generation?), evolution only occurs in populations of whole organisms. Try to use more accurate terminology please.--Alun 07:37, 29 Apr 2005 (UTC)
[edit] New Research Suggests Tumors Engender Development of Metastatic Niche (Angiogenesis) Prior to Actual Metastasis
A recent article in Nature VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche suggests that angiogenesis occurs before metastasis and that the cancer mestasizes to the site of the angiogenisis. guk,o.o,lnve kjf5rtyuiopsdfghjklertyuiop[
[edit] DII4
New chemical has been identified at Karolinska Institutet, source: http://www.dn.se/DNet/jsp/polopoly.jsp?d=597&a=611356&rss=1400
should be published in Nature soon.
Nsoltani 19:49, 28 January 2007 (UTC)
I changed the reference to a Nature paper, since the previously supplied reference was in Finnish; this is the English version of Wikipedia, so a reference in Finnish seems inappropriate (or at least not helpful). Gacggt 13:46, 29 March 2007 (UTC)
[edit] Angiopoietins
Strangely, there was no section on Ang1 or Ang2; so that was added.
Also, some of the less scientific wording was removed ("wanton destruction" etc).
Gacggt 13:01, 29 March 2007 (UTC)
[edit] Anti-angiogenesis cancer strategy
There was a claim that Dr. Folkman was the first to coin the term "anti-angiogenesis", and the first to suggest this as an anti-cancer strategy. While Dr. Folkman has been perhaps the best-known and strongest proponent of this strategy, it seems like such strong claims should be referenced before being included. So that sentence was removed pending some proof of the claim. I hope that is all right...
Can someone please provide a reference?
Gacggt 13:00, 29 March 2007 (UTC)
