Talk:Amyloid beta
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[edit] Diseases involving amyloid beta
I've reverted a change that specified Alzheimer's as only disease involving Aβ. Both cerebral amyloid angiopathy and dementia with Lewy bodies are also characterized by the aggregation of this peptide. --Ipeltan 01:42, 24 April 2006 (UTC)
[edit] Correction to above
I was the one who changed this, because amyloid "plaques" are not seen in pure congophilic amyloid angiopathy. Rather, CAA is characterized by amyloid deposition in the walls of cerebral vessels, but not parenchymal plaques. CAA can accompany AD, but it best to consider them as separate entities. Similarly, amyloid plaques are not part of the diagnostic criteria for Lewy body dementia, and are not an essential characteristic of the disease. Amyloid plaques and Lewy bodies can sometimes co-exist in substantial numbers in the cerebral cortex; in those cases, dual diganoses of AD and LBD, or alternatively use of the term "Lewy body variant" of AD, are warranted. Thus, the statement as it stands is incorrect - in neurologic disorders, amyloid plaques (generally of the neuritic variety) are a specific feature of AD, and are not charcateristic of any other neurologic disorder. However, since you have seen fit to change it back, I will wait for you to correct it. --Ve ri tas, 24 April 2006
- Since this article is about amyloid beta rather than congophilic plaques, I think it's important to mention these other diseases in which deposits of this specific peptide are seen. This is particularly true since "amyloid plaque" is a term often used to describe the fibrillar structure of pathologic protein aggregates not containing a fragment of APP. I agree, however, that CAA represents a fundamentally different form of Abeta deposit. I've made an update along these lines. Feel free to make further changes back. --Ipeltan 06:29, 14 June 2006 (UTC)
[edit] Amyloid precursor protein
Since Amyloid precursor protein redirects here, it would be nice to say something about it. It may not be important to the pathogenesis of Alzheimer's, but it's natural for an enquiring mind to wonder what this thing is in its own right. We could mention it purely to dismiss it as irrelevant, but it would be better to say something positive.
I'd write something myself, but i know nothing - that's why i came here.
A recent paper called Unraveling in vivo functions of amyloid precursor protein: insights from knockout and knockdown studies might be a good place to start. Other reviews to look at would be The amyloid precursor protein and postnatal neurogenesis/neuroregeneration and The amyloid precursor protein and its network of interacting proteins: physiological and pathological implications.
-- Tom Anderson 2006-10-30 17:22 +00:00
[edit] Abeta normal role ?
Since Abeta peptide is produced in healthy brain as well as in diseased brain, does anyone know the normal role of this peptide ? And if it has neurotrophic role, would that mean that inhibition of beta and/or gamma sercetases would be bad ? Igoruha 10:03, 28 December 20006 (UTC)
- I went to a talk on the subject a few months back, and this exact question was posed to the presenter (but not by me, I'm shy). He responded that the protein's role is not yet known. That was about four months ago, and I have heard nothing that would suggest that we may have learned much more about it. – ClockworkSoul 22:11, 28 December 2006 (UTC)
