Aminorex
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Aminorex
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| Systematic (IUPAC) name | |
| 5-phenyl-4,5-dihydro-1,3-oxazol-2-amine | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C9H10N2O |
| Mol. mass | 162.19 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Aminorex is an anorectic stimulant drug of the 2-Amino-5-Aryloxazoline class. It is closely related to the popular drug 4-methyl-aminorex. It was discovered in 1960 by McNeil Laboratories, and was quickly found in 1962 to have an appetite suppressant effect in rats. It was introduced as a prescription anorectic in Germany, Switzerland and Austria in 1965 but was soon withdrawn when a number of occurrences of pulmonary hypertension including a number of fatalities were reported. The drug reappeared as a designer analog of 4-methyl-aminorex in the US during the 1990s. It is, in fact, 4 times stronger than 4-methyl-aminorex and the 4-fluoro analog is listed as four times as potent again as an anorectic (in rats), but is unknown outside the laboratory. Aminorex has been shown to have a locomoter stimulant properties lying midway between dextroamphetamine and methamphetamine.
The simple synthetic routes available mean that future outbreaks of abuse of this drug seem likely, however the requirement for highly toxic precursors such as cyanogen bromide make the synthesis of aminorex and its derivatives potentially very dangerous for inexperienced clandestine chemists.
[edit] See also
- 4-methyl-aminorexTemplate:Psychedelic-stub
