Alpidem

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Alpidem
Systematic (IUPAC) name
2-[3-chloro-8-(4-chlorophenyl)-1,7-diazabicyclo[4.3.0] nona-2,4,6,8-tetraen-9-yl]-N,N-dipropyl-acetamide
Identifiers
CAS number	82626-01-5
ATC code	?
PubChem	54897
Chemical data
Formula	C₂₁H₂₃Cl₂N₃O
Mol. mass	404.332 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Alpidem (marketed under the brand name Ananxyl®) is a prescription drug used for the treatment of moderate to severe anxiety. Alpidem, a fairly new drug, is not in wide use. In pure form, it is only available generically, but is an additional substance in a few prescription anxiolytic drugs. Alpidem acts selectively on the omega 1 (BZ1) receptor subtype, a benzodiazepine receptor. However, it is not considered of the benzodiazepine class, but is rather an imidazopyridine. Alpidem is a close relative of zolpidem, but does not possess zolpidem's sedative property.

[edit] Indications

Alpidem is generally prescribed to patients with moderate to severe anxiety. Most of these patients have exhibited either sensitivity or resistance to benzodiazepine therapy, and therefore switched to a non-benzodiazepine medication. Alpidem does not produce significant, if any, sedative or hypnotic action. Alpidem is also used as an anticonvulsant at much higher doses.^{[citation needed]}

[edit] See also

[edit] References and notes

Zivkovic B, Morel E, Joly D, Perrault G, Sanger DJ, Lloyd KG.. "Pharmacological and behavioral profile of alpidem as an anxiolytic." Synthelabo Recherche, L.E.R.S., Bagneux, France. 1990 May;23 Suppl 3:108-13. PMID 1974069
Sanger DJ, Zivkovic B.. "Discriminative stimulus effects of alpidem, a new imidazopyridine anxiolytic." Synthelabo Recherche, Bagneux, France. 1994 Jan;113(3-4):395-403. PMID 7862851