Acetohydroxamic acid
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Acetohydroxamic acid
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| Systematic (IUPAC) name | |
| ethanehydroxamic acid | |
| Identifiers | |
| CAS number | |
| ATC code | G04 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C2H5NO2 |
| Mol. mass | 75.0666 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Acetohydroxamic acid or AHA is a urological drug. Specifically, it is a potent and irreversible inhibitor of bacterial and plant urease. The molecule is similar to urea but is not hydrolyzable by the urease enzyme. (Fishbein and Carbone, 1965)
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| Acidifiers | Ammonium chloride, Calcium chloride |
| Urinary antispasmodics | Darifenacin, Emepronium, Flavoxate, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium |
| For erectile dysfunction | Alprostadil, Apomorphine, Avanafil, Moxisylyte, Papaverine, Phentolamine, Sildenafil, Tadalafil, Udenafil, Vardenafil, Vendafidel, Yohimbine |
| Other urologicals | Acetohydroxamic acid, Collagen, Dimethyl sulfoxide, Magnesium hydroxide, Phenazopyridine, Phenyl salicylate, Succinimide |
| For benign prostatic hypertrophy | 5α-reductase inhibitors: Dutasteride, Finasteride Alpha blockers: Alfuzosin, Doxazosin, Tamsulosin, Terazosin |
[edit] Notes
References J Biol Chem. 1965 Jun;240:2407-14. W. Fishbein and P. Carbone
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