5-HT3

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The 5-HT₃ receptors are excitatory ligand-gated cation channel receptors, a unique property in the 5-HT receptor family. Therefore, it is a serotonin receptor subtype. It has been linked to alcoholism and nausea. 5-HT3 serotonin receptors are found both in the central and enteric nervous system.

5-hydroxytryptamine (serotonin) receptor 3A
Identifiers
Symbol	HTR3A HTR3
HUGO	5297
Entrez	3359
OMIM	182139
RefSeq	NM_000869
UniProt	P46098
Other data
Locus	Chr. 11 q23.1-23.2

5-hydroxytryptamine (serotonin) receptor 3B
Identifiers
Symbol	HTR3B
HUGO	5298
Entrez	9177
OMIM	604654
RefSeq	NM_006028
UniProt	O95264
Other data
Locus	Chr. 11 q23.1

The correct title of this article is 5-HT₃. It features superscript or subscript characters that are substituted or omitted because of technical limitations.

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1 Structure
2 Function
3 References
4 External links

[edit] Structure

Their structure is a 4 transmembrane homopentameric structure consisting of α-subunits and a β-subunit with the possibility though of a heteropentameric structure existing instead.

The receptor consists of α- and β-subunits of structure similar to the α-subunits of nicotinic acetylcholine receptors with 27% homology, GABA_A receptor and strychnine-sensitive glycine receptor with 22%.

The approximate molecular size is 259 kilodaltons, with both the C-terminus and N-terminus being extracellular, a typical feature of the ligand-gated ion channel receptors.

[edit] Function

The 5-HT₃ receptors situated in the presynaptic vagal afferents, the area postrema and gastrointestinal tract seem to be important in emetic response activation and regulation.

[edit] References

IUPHAR (2005). IUPHAR receptor database Retrieved on February 11, 2007.
Karim F. (1996). “Role of 5-Hydroxytryptamine3 (5-HT3) Antagonists in Prevention of Emesis Caused by Anticancer Therapy”. Biochemical Pharmacology, Volume 52, Issue 5, Pages 685-692. PMID 8765466. Retrieved on February 11, 2007.
Naylord RJ, Rudd JA. (1994). “Emesis and Anti-emesis” Cancer Surveys, Volume 21, Pages 117-135. PMID 8564988. Retrieved on February 11, 2007.
Kelley, S.P., Dunlop, J.I., Kirkness, E.F., Lambert, J.J. and Peters, J.A. (2003). A cytoplasmic region determines single channel conductance in 5-HT3 receptors. Nature, 424(6946): 321-324.