Talk:5-alpha-reductase deficiency
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[edit] discussion of the article
The book Middlesex, an amazing book, is narrated by Cal who has 5 alpha reductase deficiency and provides a very interesting look at the social ramifications of such a condition. I highly recommend the book, it is very well done. ISBN 0312422156
Edited "testes" to "testicles" for article tone consistency.
Does no one think it appropriate to include the 'Guevodoces'/Dominican Republic information? Varilux 07:31, 3 November 2005 (UTC)
5-alpha reductase deficiency is a syndrome which can be inherited due to inbreeding or genetic founder effects. This is the case for the "guevedoces" (literally penis at age twelve) in the small town of Salinas, Dominican Republic as well as other isolate communities around the world. It is the impairment of the 5-alpha reductase enzyme which converts the androgen testosterone into its more potent metabolite dihydrotestosterone, or DHT. DHT in utero is responsible for the masculinization of external genitalia and for growth of the prostate gland, as well as some other secondary sexual characteristics, such as acne or beard/facial hair growth. Without 5-alpha reductase, testosterone alone is not potent an androgen enough to fully masculinize the genitalia of an XY individual in utero, resulting in erroneous sexing at birth. At puberty, however, there is a spike in the production of testosterone (as well as other steroid hormones) which bind to the same receptors as that of DHT, which can lead to the sex-altering growth of male muscles, penis, and testes, though usually of subnormal size in the phenotypically female individual.
Would you regulars consider the Quentin bit to be a spoiler?
In my opinion, the book deserves a one sentence allusion in an article like this rather than a synopsis. That serves to alert the reader interested in the topic that the book exists. We have many articles about novels or works of fiction. If you would like to treat the book more fully, make a separate Middlesex article, put in as much detail as you want, and include a spoiler warning like we usually do. My opinion of course. alteripse 23:11, 23 December 2005 (UTC) Oh look, the link turned blue, so we already do have such an article, and that is where I would put details.
[edit] Combine with 'Guevedoche'?
There is an existing page under the spelling 'Guevedoche'. I have cross-referrenced that page with this (and added medical and documentary external links to both) but I think they could be combined.
- I agree. Only if the name remains "5-alpha-reductase deficiency" :-). Guevedoche is probably the term used to describe the transition during pubertal virilization (I'll look it up, I remember a translation like 'penis at 12'). The Dominican Republic, also Papua New Guiney, have higher incidences of 5-alpha-reductase deficiency-2, probably caused by higher incidence of consanguinity. ---Chbse
- I disagree. Guevedoce is more appropriate to talk about the social side of it, and in particularl the effect in PNG and the dominican republic. Cheers! Lauren♫/∆ 00:27, 2 April 2007 (UTC)
[edit] Reproduction?
It's generally reported that patients with 5ARD-2 are primarily infertile, due to underdevelopment of seminal vesicles and prostate gland, not to mention the large amount of undescended (non-scrotal) testis found in 2ARD-2 patients (Houk, 2005; Cohen-Kettenis P., 2005). There have been some reports of fathering patients (Grant; 1996, Nordenskjold; 1998, KatzMD; 1997, Ivarsson ;1995), but worldwide there has been little proof of genetic fathering (biological fathers). I'll look up viability of articles (briefly) mentioned above (genitic testing in "fathers" etc.). ---Chbse
- Those links would be great to add to the "reproduction" section. Absolutely, they tend to be unable to reproduce without medical intervention. It is tied up in the issue of their gender identity, too; those who identify as "straight women" are unlikely to want to "father" children.
- Most IVF techniques are appropriate, assuming the individual hasn't had genital mutilation or gonadectomy due to their intersex status which prevents this.
- Cheers! Lauren♫/∆ 00:22, 2 April 2007 (UTC)
[edit] See also
What do you think of adding 17βHSD3 to the "list". Androgen insensitivity has little to do with testosterone biosynthesis... ---Chbse
- I assume you mean "17-beta-hydroxysteroid dehydrogenase isoenzyme 3 deficiency"? It can certainly go in the "see also" but is already on the "Intersex" page list. BTW, looking at it, it definately needs a cleanup, don't it?
- Cheers! Lauren♫/∆ 00:26, 2 April 2007 (UTC)
- 17-beta-hydroxysteroid dehydrogenase isoenzyme 3 deficiency is often abbreviated to the simpler word 17βHSD3. Will certainly work on that page :-). Greetz Chbse
