3,4-Diaminopyridine

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3,4-Diaminopyridine
Systematic (IUPAC) name
3,4-Diaminopyridine
Identifiers
CAS number	54-96-6
ATC code	?
PubChem	?
Chemical data
Formula	C₅H₇N₃
Mol. mass	109.13
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

3,4-Diaminopyridine is an experimental drug used in the treatment of Lambert-Eaton Syndrome. In Lambert-Eaton Syndrome, acetylcholine release is inhibited as antibodies meant to target characteristic cancers target Ca²⁺ channels on the prejunctional membrane instead. 3,4-Diaminopyridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is increased. Ca²⁺ channels can then be open for longer time and allow greater acetylcholine release to stimulate muscle at end plate.