2C-B

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2C-B
Chemical name	4-Bromo-2,5-dimethoxy-phenethylamine or 2-(4-bromo-2,5-dimethoxyphenyl)-1-aminoethane
Chemical formula	C₁₀H₁₄BrNO₂
Molecular mass	260.13 g/mol
Melting point	237 - 239 °C decomposition (hydrochloride) 215 °C (hydrobromide) 208 - 209 °C (acetate)
CAS number	66142-81-2
SMILES	NCCC1=C(OC)C=C(Br)C(OC)=C1

2C-B, or 4-bromo-2,5-dimethoxyphenethylamine, is a lesser-known psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin in 1974. In his book PIHKAL (Phenethylamines I Have Known and Loved), the dosage range is listed as 16–24 mg. 2C-B is sold as a white powder sometimes pressed in tablets or gel caps. The drug is usually taken orally, but sometimes is insufflated.

1 Origins and history
2 Toxicity and dosage
3 Effects
4 References
5 See also
6 External links
7 Categorization

[edit] Origins and history

2C-B was synthesized from 2-5-dimethoxybenzaldehyde by Alexander Shulgin in 1974. Internationally, 2C-B is a Schedule II drug under the Convention on Psychotropic Substances^[1]. In the United States, a notice of proposed rulemaking published on December 20, 1994 in the Federal Register (59 FR 65521) and after a review of relevant data, the Deputy Administrator of the Drug Enforcement Administration (DEA) proposed to place 4-bromo-2,5-DMPEA into Schedule I, making 2C-B illegal in the United States. This became permanent law July 2, 1995. Prior to this, 2C-B was commercially available as an aphrodisiac under the tradename "Eros" which was manufactured by the German phamaceutical company Drittewelle. Recently 2C-B has been distributed under the street name "Nexus". Other street names include "Venus", "Bees", and (incorrectly) "bromo-mescaline".

[edit] Toxicity and dosage

2C-B pill with heart logo.

The September 1998 Journal of Analytical Toxicology reported that very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-B. The relationship between its use and disease and death are unknown.^[2] At oral doses around 5–15 mg, 2C-B produces an entactogenic effect. But common recreational doses range from 15–40 mg, at which intense visual and auditory effects are experienced. The intensity of the effects increases with dosage^[3].

[edit] Effects

Effects of 2C-B include^[4].:

Major effect on body awareness; tendency to bring out internal bodily imperfections previously unknown to the user.
Some recreational users report mild diarrhoea, gas, nausea, and rarely vomiting. The drug is much lighter on the body than MDMA (Ecstasy), with an easier comedown.
The hallucinations have a tendency to decrease and then increase in intensity, giving the users a sense of "waves", and are popularly described as "clichéd 70's visuals".
Users describe effects as a mix between LSD and MDMA, although unlike a combination of the two. 2C-B is reportedly less dissociative and controlling than LSD, and less directive and speedy than MDMA. The drug has a mild stimulative effect, positive mood shift, both very mild compared to LSD or MDMA.
Some users report an aphrodisiac-like effect, though the body distortional effects are considered a "turn-off".
Inappropriate giggling or smiling is common.
Decline of visual acuity.
At low doses the experience erratically and unexpectedly switches from intensely engaged to suddenly sober. Experienced users report the ability to take control of the above effect and switch from engaged to sober at will.

The following effects are highly dose-dependent.

Strongly affects ability to verbally communicate, engage in deep thought, or maintain attention span.
Open Eye Visuals (OEVs), such as cartoon-like distortions and red or green halos around objects are common. Closed Eye Visuals (CEVs) are more common than OEVs.
Some users report experiencing frightening or fearful effects during the experience. Users describe feeling frigid or cold on reaching a plateau.
Coordination is affected, some users lose balance or have perceptual distinction problems.