21-Hydroxylase
From Wikipedia, the free encyclopedia
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cytochrome P450, family 21, subfamily A, polypeptide 2
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| Identifiers | |
| Symbol | CYP21A2 CYP21, CYP21B |
| HUGO | 2600 |
| Entrez | 1589 |
| OMIM | 201910 |
| RefSeq | NM_000500 |
| UniProt | P08686 |
| Other data | |
| EC number | 1.14.99.10 |
| Locus | Chr. 6 p21.3 |
21-Hydroxylase (or Steroid 21-β-Monooxygenase) is an enzyme which is involved with the biosynthesis of the steroid hormones aldosterone and cortisol.
The CAS number is 9029-68-9.
21-Hydroxylase is formed by the gene CYP21B.
Contents |
[edit] Reaction
It catalyzes an oxidation of the carbon atom 21 in steroids (adding an "-OH"), which is necessary with the formation of these hormones.
 Steroid numbering - #21 is near center top |
[edit] Pathway
[edit] Clinical significance
A defect within the CYP21B gene causes a disturbance of the development of the enzyme, which to Congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
[edit] See also
[edit] External links
- Synthesis of Desoxycorticosterone from Progesterone through 21-Hydroxylase (Image)
- MeSH Steroid+21-Hydroxylase
Side-chain cleavage - 21-hydroxylase - 18-hydroxylase - 11-beta-hydroxylase
