Talk:Zonisamide

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I am not quite sure not being a pharmacist myself, but the following sentence seems to contain an error:"...increasing the levels of the glutamate transport protein in the brain while decreasing the amount of GABA transport protein, in other words, inhibiting the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate."

AEDs usually enhance GABA activiy or release and inhibit Glutamate (not the other way round) in order to depotentiate the neuron and thus preventing or lowering voltage below the seizure threshold.

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I'm pretty sure some doctors are also experimenting with using this as a migraine preventative, as with many other anticonvulsants. Blahity 04:13, 26 October 2006 (UTC) My clever reasoning above is that I'm on it for that. My neurologist supposedly specializes in headaches (Dr. Schulman at Lankenau Hospital near Philadelphia) and he's trying it in a manner similar to the use of Topamax for the purpose. It's a fairly new medication and I don't know if theres any literature on the subject of the use, just thought I'd write it here, and clarify my reasoning. 71.224.32.208 07:12, 17 November 2006 (UTC)