ZFYV9E (protein)
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| Zinc finger FYVE domain-containing protein 9 (SARA) | |
|---|---|
| Symbol(s): | ZFYVE9 MADHIP |
| Other names: | Mothers against decapentaplegic homolog-interacting protein, Madh-interacting protein, Smad anchor for receptor activation, Receptor activation anchor, hSARA, Novel serine protease, NSP |
| Protein Structure/Function | |
| Protein type: | Anchoring protein |
| Domains: | 2 FYVE domains |
| Other | |
| Taxa expressing: | Homo sapiens; homologs: many metazoan phyla |
| Cell types: | ubiquitous |
| Subcellular localization: | Cytoplasm |
| Database Links | |
| Entrez: | 9372 |
| OMIM: | 603755 |
| UniProt: | O95405 |
Zinc finger FYVE domain-containing protein 9 or SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors. It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.
| TGF beta signaling pathwayedit | |
|---|---|
| TGF beta superfamily of ligands: | |
| Activin A | Activin B | Anti-müllerian hormone | BMP2 | BMP3 | BMP4 | BMP5 | BMP6 | BMP7 | BMP8a | BMP8b | BMP10| BMP15 | GDF1 | GDF2 | GDF3 | GDF5 | GDF6 | GDF7 | GDF9 | GDF10 | GDF11 | GDF15| Inhibin A | Inhibin B | Myostatin | Nodal | TGFβ1 | TGFβ2 | TGFβ3 | |
| Type II receptors: ACVR2A | ACVR2B | AMHR2 | BMPR2 | TGFBR2 | TGFBR3 | |
| Type I receptors: ACVR1A | ACVR1B | ACVR1C | ACVRL1 | BMPR1A | BMPR1B | TGFBR1 | |
| Signal transducers: SMAD1 | SMAD2 | SMAD3 | SMAD4 | SMAD5 | SMAD6 | SMAD7 | SMAD9 | |
| Ligand Inhibitors: Cerberus | Chordin | DAN | Decorin | Follistatin | Gremlin | Lefty | LTBP1 | Noggin | THBS1 | |
| Coreceptors: BAMBI | Cripto Other: SARA |
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