Vulvar intraepithelial neoplasia

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The term vulvar intraepithelial neoplasia (VIN) denotes a squamous intraepithelial lesion of the vulva that shows dysplasia with varying degrees of atypia. The epithelial basement membrane is intact and the lesion is thus not invasive but has invasive potential.

1 ISSVD Classification
2 Diagnosis
3 Treatment
4 References
5 External links

[edit] ISSVD Classification

The terminology of VIN evolved over several decades. In 1989 the Committee on Terminology, International Society for the Study of Vulvar Disease (ISSVD) replaced older terminology such as vulvar dystrophy, Bowen's disease, and Krausosis vulvae by a new classification system for Epithelial Vulvar Disease:

Nonneoplastic epithelial disorders of vulva and mucosa:
- Lichen sclerosus
- Squamous hyperplasia
- Other dermatoses
Mixed neoplastic and nonneoplastic disorders
Intraepithelial neoplasia
- - Squamous vulvar intraepithelial neoplasia (VIN)
    - VIN I, mildest form
    - VIN II, intermediate
    - VIN III, most severe form including carcinoma in situ of the vulva
  - Non-squamous intraepithelial neoplasia
    - Extramammary Paget's disease
    - Tumors of melanocytes, non invasive]]
Invasive disease (vulvar carcinoma)

[edit] Diagnosis

The patient may have no symptoms, or local symptomatology including itching, burning, and pain. The diagnosis is always based on a careful inspection and a targeted biopsy.

[edit] Treatment

The treatment of VIN is local to wide excision, in case of very extensive involvement or recurrency even a simple vulvectomy. Laser therapy has also been useful for VIN.