Vesicular monoamine transporter
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solute carrier family 18 (vesicular monoamine), member 1
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| Identifiers | |
| Symbol(s) | SLC18A1 VMAT1, VAT1 |
| Entrez | 6570 |
| OMIM | 193002 |
| RefSeq | NM_003053 |
| UniProt | P54219 |
| Other data | |
| Locus | Chr. 8 p21.3 |
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solute carrier family 18 (vesicular monoamine), member 2
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| Identifiers | |
| Symbol(s) | SLC18A2 VMAT2 |
| Entrez | 6571 |
| OMIM | 193001 |
| RefSeq | NM_003054 |
| UniProt | Q05940 |
| Other data | |
| Locus | Chr. 10 q25 |
The vesicular monoamine transporter is a transport protein located within the presynaptic cell. It comprises the two isoforms VMAT1 and VMAT2.
Contents |
[edit] VMAT2
[edit] Impairment and Dysfunction
Cocaine users display a marked reduction in VMAT2 immunoreactivity. Suffers of cocaine-induced mood disorders displayed a significant loss of VMAT2 immunoreactivity, this might reflect damage to striatal dopamine fibers. These neuronal changes could play a role in causing disordered mood and motivational processes in more severely addicted users.[1]
[edit] Binding Sites and Ligands
One binding site is that of DTBZ. Lobeline binds at this site. At a distinct site dextroamphetamine binds. Its activity at VMAT2 is a crucial part of its monoamine releasing action.
[edit] References
- ^ K.Y. Little et al. (2003). Am J Psychiatry 160, 47-55. Loss of Striatal Vesicular Monoamine Transporter Protein (VMAT2) in Human Cocaine Users
[edit] Further reading
- Kilbourne, M.R. (1997) In Vivo Radiotracers for Vesicular Neurotransmitter Transporters. Nuclear Medicine & Biology, Vol.24, pp.615-619.
- Weihe, E. and Eiden, L.E. (2000) Chemical neuroanatomy of the vesicular amine transporter. FASEB J, Vol.14, pp.2435-2449.
[edit] External links
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