VAMP

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Vesicle associated membrane protein (VAMP) family of proteins includes proteins with similar structure.

• VAMP-1 and VAMP-2 proteins known as synaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate in neuromediator release.

• VAMP-3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles.

• VAMP-5 and VAMP-7 participate in constitutive exocytosis. VAMP-5 is constituent of secretory vesicles, myotubes and tubulovesicular structures, while VAMP-7 is found both in secretory granules and endosomes.

• VAMP8 (known as endobrevin) participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.